Repeated low-level red-light (RLRL), characterized by increased energy supply and cellular metabolism, thus enhancing metabolic repair processes, has gained persistent worldwide attention in recent years as a new novel scientific approach for therapeutic application in myopia. This therapeutic revolution led by RLRL therapy is due to significant advances in bioenergetics and photobiology, for instance, enormous […]
Optical stimulation of mitochondria reduces blood glucose levels
Abstract Mitochondria regulate metabolism, but solar light influences its rate. Red light increases mitochondrial membrane potentials and ATP production and may increase glucose demand. Here we show, with a glucose tolerance test, that red light exposure in normal subjects significantly reduces blood sugar levels. A 15 min exposure to 670 nm light, reduced the degree […]
Photobiomodulation at Defined Wavelengths Regulates Mitochondrial Membrane Potential and Redox Balance in Skin Fibroblasts
Starting from the discovery of phototherapy in the beginning of the last century, photobiomodulation (PBM) has been defined in late 1960s and, since then, widely described in different in vitro models. Robust evidence indicates that the effect of light exposure on the oxidative state of the cells and on mitochondrial dynamics, suggesting a great therapeutic potential. The […]
Shedding light on the importance of autophagy in AMD
Autophagy is a protective process that prevents oxidative damage in the eye. Recognition of this provides researchers with a new pathway to deal with age-related macular degeneration (AMD) and other retinal pathologies, according to Roberto Pinelli, MD, CEO and founder of the Switzerland Eye Research Institute, Lugano, Switzerland. He described the latest ideas about the […]
Transcranial photobiomodulation for the brain: a wide range of clinical applications
Photobiomodulation therapy (PBMT) is a rapidly growing approach to the healing, stimulation, protection, and regeneration of many human organs and tissue types. PBMT started in the 1960s as low-level laser therapy for wound healing, but since then the introduction of light-emitting diodes (LEDs) has dramatically increased the number of applications and reports of positive results. […]
PHOTOBIOMODULATION THERAPY FOR LARGE SOFT DRUSEN AND DRUSENOID PIGMENT EPITHELIAL DETACHMENT IN AGE-RELATED MACULAR DEGENERATION: A Single-Center Prospective Pilot Study
Abstract Purpose: To evaluate visual acuity and morphologic changes after photobiomodulation (PBM) for patients affected with large soft drusen and/or drusenoid pigment epithelial detachment associated with dry age-related macular degeneration. Method: Twenty eyes with large soft drusen and/or drusenoid pigment epithelial detachment age-related macular degeneration were included and treated using the LumiThera Valeda Light Delivery System. All […]
The Effects of Modulated Light on the Visual Process
INTRODUCTION Light as medicine may seem like a new concept, but scientists have known since at least the late 1800s that certain wavelengths of light in prescribed doses can be used to heal the tissue [1,2]. For the eye and vision care community, light is being used as Intense Pulsed Light Therapy (IPL) for dry […]
Improvements in Gulf War Illness Symptoms After Near-Infrared Transcranial and Intranasal Photobiomodulation: Two Case Reports
Abstract At least one-fourth of US veterans who served in the 1990–1991 Gulf War (GW) are affected by the chronic symptomatic illness known as Gulf War illness (GWI). This condition typically includes some combination of fatigue, headaches, cognitive dysfunction, musculoskeletal pain, and respiratory, gastrointestinal and dermatologic complaints. To date, effective treatments for GWI have been […]
Improvements in clinical signs of Parkinson’s disease using photobiomodulation: a prospective proof-of-concept study
Abstract Background: Parkinson’s disease (PD) is a progressive neurodegenerative disease with no cure and few treatment options. Its incidence is increasing due to aging populations, longer disease duration and potentially as a COVID-19 sequela. Photobiomodulation (PBM) has been successfully used in animal models to reduce the signs of PD and to protect dopaminergic neurons. Objective: To assess […]
Transcranial Photobiomodulation Treatment: Significant Improvements in Four Ex-Football Players with Possible Chronic Traumatic Encephalopathy
Abstract Background: Chronic traumatic encephalopathy, diagnosed postmortem (hyperphosphorylated tau), is preceded by traumatic encephalopathy syndrome with worsening cognition and behavior/mood disturbances, over years. Transcranial photobiomodulation (tPBM) may promote improvements by increasing ATP in compromised/stressed cells and increasing local blood, lymphatic vessel vasodilation. Objective: Aim 1: Examine cognition, behavior/mood changes Post-tPBM. Aim 2: MRI changes – […]