INTRODUCTION Light as medicine may seem like a new concept, but scientists have known since at least the late 1800s that certain wavelengths of light in prescribed doses can be used to heal the tissue [1,2]. For the eye and vision care community, light is being used as Intense Pulsed Light Therapy (IPL) for dry […]
Abstract At least one-fourth of US veterans who served in the 1990–1991 Gulf War (GW) are affected by the chronic symptomatic illness known as Gulf War illness (GWI). This condition typically includes some combination of fatigue, headaches, cognitive dysfunction, musculoskeletal pain, and respiratory, gastrointestinal and dermatologic complaints. To date, effective treatments for GWI have been […]
Abstract Background: Parkinson’s disease (PD) is a progressive neurodegenerative disease with no cure and few treatment options. Its incidence is increasing due to aging populations, longer disease duration and potentially as a COVID-19 sequela. Photobiomodulation (PBM) has been successfully used in animal models to reduce the signs of PD and to protect dopaminergic neurons. Objective: To assess […]
Abstract Background: Chronic traumatic encephalopathy, diagnosed postmortem (hyperphosphorylated tau), is preceded by traumatic encephalopathy syndrome with worsening cognition and behavior/mood disturbances, over years. Transcranial photobiomodulation (tPBM) may promote improvements by increasing ATP in compromised/stressed cells and increasing local blood, lymphatic vessel vasodilation. Objective: Aim 1: Examine cognition, behavior/mood changes Post-tPBM. Aim 2: MRI changes – […]
Abstract Objective: This study investigated whether patients with mild to moderately severe dementia or possible Alzheimer’s disease (AD) with Mini-Mental State Exam (MMSE) Baseline scores of 10–24 would improve when treated with near-infrared photobiomodulation (PBM) therapy. Background: Animal studies have presented the potential of PBM for AD. Dysregulation of the brain’s default mode network (DMN) has been […]
Abstract Objective: To examine the effects of transcranial and intranasal photobiomodulation (PBM) therapy, administered at home, in patients with dementia. Background: This study sought to replicate and build upon a previously published case series report describing improved cognitive function in five patients with mild-to-moderate dementia after 12 weeks of transcranial and intranasal near-infrared (NIR) PBM therapy. Materials […]
Abstract Purpose : The retina declines both structurally and functionally with age, with mitochondria playing a key role. Red to near-infrared (R-NIR) light in the region of λ670nm improves mitochondrial function and has been associated with improvements in color contrast sensitivity in preliminary studies of human retinal aging. This study tests the hypothesis that R-NIR light improves […]
Purpose : There are currently few treatment options available for the progression of RPE atrophy in non-exudative age-related macular degeneration (AMD). It is believed that individual oxidative stress, like in smoking, is a major clinical disease factor. In-vitro data demonstrate the protective anti-oxidative effect of photobiomodulation (PBM) when different wavelengths (in the visible and near-infrared range) of […]
Abstract Importance Myopia is a global concern, but effective prevention measures remain limited. Premyopia is a refractive state in which children are at higher risk of myopia, meriting preventive interventions. Objective To assess the efficacy and safety of a repeated low-level red-light (RLRL) intervention in preventing incident myopia among children with premyopia. Design, Setting, and Participants This was […]
Abstract An ischemic stroke typically accompanies numerous disorders ranging from somatosensory dysfunction to cognitive impairments, inflicting patients with various neurologic symptoms. Among pathologic outcomes, post-stroke olfactory dysfunctions are frequently observed. Despite the well-known prevalence, therapy options for such compromised olfaction are limited, likely due to the complexity of olfactory bulb architecture, which encompasses both the […]