Since the growing popularity of repeated low-level red light (RLRL) in the past decade for myopia control, many researchers have been trying to understand the mechanism behind this treatment. RLRL therapy results do not match with classical emmetropization theory in that red light, which is a long wavelength, would focus behind the retina and therefore induce […]
Photobiomodulation use in ophthalmology – an overview of translational research from bench to bedside
Photobiomodulation (PBM) refers to the process in which wavelengths of light are absorbed by intracellular photoacceptors, resulting in the activation of signaling pathways that culminate in biological changes within the cell. PBM is the result of low-intensity light-induced reactions in the cell in contrast to thermal photoablation produced by high-intensity lasers. PBM has been effectively […]
Effect of low-level light therapy in individuals with dry eye disease
Abstract Introduction: Low-level light therapy (LLLT) or photobiomodulation, the application of red light to the eye, is used for the treatment of dry eye. Limited studies have investigated the efficacy of LLLT as a stand-alone treatment. The investigation aimed to evaluate the effect of LLLT on signs and symptoms of dry eye. Methods: Participants with mild to […]
Photobiomodulation for Early Dry AMD Gets Enthusiastic Reception
STOCKHOLM — A form of low-level light to stimulate cellular energy production achieved durable improvement in visual acuity in early-intermediate geographic atrophy (GA), a multicenter, sham-control study showed. Patients randomized to photobiomodulation (PBM) had a five- to six-letter improvement in best corrected visual acuity (BCVA) at 12 and 24 months. Most patients in the control […]
Photobiomodulation Using Light-Emitting Diode (LED) for Treatment of Retinal Diseases
Abstract: Photobiomodulation (PBM) is a type of phototherapy that employs light-emitting diodes (LEDs) or low-power lasers to selectively administer specific wavelengths of visible light, ranging from 500 to 1000 nm, including near-infrared (NIR) wavelengths. LEDs are advantageous compared to lasers due to their ability to treat large areas at a lower cost, lack of tissue damage […]
Myopia Control Effect of Repeated Low-Level Red-Light Therapy Combined with Orthokeratology: A Multicenter Randomized Controlled Trial
Abstract Purpose To investigate the efficacy and safety of repeated low-level red-light(RLRL) therapy combined with orthokeratology(Ortho-k) among the children who, despite undergoing Ortho-k treatment, exhibited an axial elongation of at least 0.50mm over 1 year. Design Multicenter, randomized, parallel-group, single-blind clinical trial (ClinicaTrials.gov,NCT04722874). Participants Eligible children were aged 8-13 years with a cycloplegic spherical equivalent […]
Effects of slit lamp-delivered retinal laser photobiomodulation in a rat model of choroidal neovascularization
Abstract Neovascular age-related macular degeneration, also known as exudative or wet age-related macular degeneration, is the leading cause of blindness in the developed world. Photobiomodulation has the potential to target the up-stream hypoxic and pro-inflammatory drivers of choroidal neovascularization. This study investigated whether photobiomodulation attenuates characteristic pathological features of choroidal neovascularization in a rodent model. […]
A retrospective study of cumulative absolute reduction in axial length after photobiomodulation therapy
Abstract Background To assess the age and timeline distribution of ocular axial length shortening among myopic children treated with photobiomodulation therapy in the real world situations. Methods Retrospective study of photobiomodulation therapy in Chinese children aged 4 to 13 years old where axial length measurements were recorded and assessed to determine effectiveness at two age […]
Daily Low-Level Red Light for Spherical Equivalent Error and Axial Length in Children With Myopia
This randomized clinical trial evaluates the efficacy and safety of daily 650-nm low-level red light for myopia treatment among children aged 6 to 12 years in China. Key Points Question What is the effect of daily 650-nm low-level red light (LLRL) on spherical equivalent error (SER) and on axial length (AL)? Findings In this randomized […]
Photobiomodulation For Dry AMD: Ready For Its Day in The Sun?
In exudative age-related macular degeneration (wet AMD), significant strides — such as the development of anti-vascular endothelial growth factor (anti-VEGF) therapies — have pushed the treatment possibilities forward and rewritten the likely course of the disease for many patients. However, for most patients, AMD is nonexudative (dry), and treatments for those patients remain largely limited.1,2 Recent developments in […]