Abstract Purpose To investigate the efficacy and safety of repeated low-level red-light(RLRL) therapy combined with orthokeratology(Ortho-k) among the children who, despite undergoing Ortho-k treatment, exhibited an axial elongation of at least 0.50mm over 1 year. Design Multicenter, randomized, parallel-group, single-blind clinical trial (ClinicaTrials.gov,NCT04722874). Participants Eligible children were aged 8-13 years with a cycloplegic spherical equivalent […]
Daily Low-Level Red Light for Spherical Equivalent Error and Axial Length in Children With Myopia
This randomized clinical trial evaluates the efficacy and safety of daily 650-nm low-level red light for myopia treatment among children aged 6 to 12 years in China. Key Points Question What is the effect of daily 650-nm low-level red light (LLRL) on spherical equivalent error (SER) and on axial length (AL)? Findings In this randomized […]
Myopia Control Effect of Repeated Low-Level Red-Light Therapy in Chinese Children: A Randomized, Double-Blind, Controlled Clinical Trial
Abstract Purpose: Repeated low-level red-light (RLRL) therapy is an emerging treatment for myopia control. Nevertheless, previous studies are limited by open-label design. Our study aimed to assess the efficacy and safety of RLRL therapy in controlling myopia progression compared to a sham device with only 10% of the original power. Design: Randomized, double-blind, controlled clinical trial. Participants: A […]
Longitudinal Changes and Predictive Value of Choroidal Thickness for Myopia Control after Repeated Low-Level Red-Light Therapy
Abstract Purpose: To evaluate longitudinal changes in macular choroidal thickness (mCT) in myopic children treated for 1 year with repeated low-level red-light (RLRL) therapy and their predictive value for treatment efficacy on myopia control. Design: A secondary analysis of data from a multicenter, randomized controlled trial (RCT; NCT04073238). Participants: Myopic children aged 8-13 years who participated in the RCT […]
Efficacy Comparison of Repeated Low-Level Red Light and Low-Dose Atropine for Myopia Control: A Randomized Controlled Trial
Abstract Purpose: To compare the treatment efficacy between repeated low-level red light (RLRL) therapy and 0.01% atropine eye drops for myopia control. Methods: A single-masked, single-center, randomized controlled trial was conducted on children 7 to 15 years old with cycloplegic spherical equivalent refraction (SER) ≤ -1.00 diopter (D) and astigmatism ≤ 2.50 D. Participants were randomly assigned […]
Effect of Repeated Low-Level Red-Light Therapy for Myopia Control in Children: A Multicenter Randomized Controlled Trial
Abstract Purpose: To assess the efficacy and safety of repeated low-level red-light (RLRL) therapy in myopia control in children. Design: Multicenter, randomized, parallel-group, single-blind clinical trial. Participants: Two hundred sixty-four eligible children 8 to 13 years of age with myopia of cycloplegic spherical equivalent refraction (SER) of -1.00 to -5.00 diopters (D), astigmatism of 2.50 D or less, […]
Axial Shortening in Myopic Children after Repeated Low-Level Red-Light Therapy: Post Hoc Analysis of a Randomized Trial
Abstract Introduction: Axial length (AL) elongation in myopia is considered irreversible. We aimed to systemically report unexpected AL shortening observed in a randomized clinical trial (RCT) after repeated low-level red-light (RLRL) therapy. Methods: This is a post hoc analysis of a multicenter, single-masked RCT. Two hundred sixty-four myopic children aged 8-13 years allocated to RLRL treatment (intervention […]
A Study on the Effectiveness of 650-nm Red-Light Feeding Instruments in the Control of Myopia
Abstract Introduction: This study analyzed the effectiveness of 650-nm red-light feeding instruments in the control of myopia. Methods: In this study, 164 school-aged participants diagnosed with myopia in the city of Shenzhen were enrolled in a red-light feeding instrument study. Of these, 41 were enrolled in the mild-to-moderate myopia group that received red-light feeding (RLMM group), 65 […]
Repeated Low-Level Red-Light Therapy for Controlling Onset and Progression of Myopia-a Review
Repeated low-level red-light (RLRL), characterized by increased energy supply and cellular metabolism, thus enhancing metabolic repair processes, has gained persistent worldwide attention in recent years as a new novel scientific approach for therapeutic application in myopia. This therapeutic revolution led by RLRL therapy is due to significant advances in bioenergetics and photobiology, for instance, enormous […]
The Effects of Modulated Light on the Visual Process
INTRODUCTION Light as medicine may seem like a new concept, but scientists have known since at least the late 1800s that certain wavelengths of light in prescribed doses can be used to heal the tissue [1,2]. For the eye and vision care community, light is being used as Intense Pulsed Light Therapy (IPL) for dry […]