Abstract Purpose : The complex pathophysiology of DME results in extracellular fluid accumulation and in decreased visual function. Light-based Photobiomodulation (PBM) provides a non-invasive treatment strategy that directly targets the underlying pathology through light-sensitive cellular cascades. The Valeda Light Delivery System is successful in the treatment of AMD (cf. LIGHTSITE I & II). We here present an […]
Photobiomodulation Therapy for Age-Related Macular Degeneration and Diabetic Retinopathy: A Review
Abstract Purpose Photobiomodulation therapy (PBT) has emerged as a possible treatment for age-related macular degeneration (AMD) and diabetic retinopathy (DR). This review seeks to summarize the application of PBT in AMD and DR. Methods The National Clinical Trial (NCT) database and PubMed were queried using a literature search strategy and reviewed by the authors. Results […]
The Potential of Visible and Far-Red to Near-Infrared Light in Glaucoma Neuroprotection
Alternative treatment strategies are necessary to reduce the severity of glaucoma, a group of eye conditions that progressively damage the optic nerve and impair vision. The aim of this review is to gain insight into potentially exploitable molecular mechanisms to slow down the death of retinal ganglion cells (RGCs), a fundamental element in the pathophysiology […]
Energy Metabolism in the Inner Retina in Health and Glaucoma
Glaucoma, the leading cause of irreversible blindness, is a heterogeneous group of diseases characterized by progressive loss of retinal ganglion cells (RGCs) and their axons and leads to visual loss and blindness. Risk factors for the onset and progression of glaucoma include systemic and ocular factors such as older age, lower ocular perfusion pressure, and […]
The Potential Effects of Light Irradiance in Glaucoma and Photobiomodulation Therapy
Human vision is mediated by the retina, one of the most critical tissues in the central nervous system. Glaucoma is a complex retinal disease attributed to environmental, genetic, and stochastic factors, all of which contribute to its pathogenesis. Historically, glaucoma had been thought of primarily as a disease of the elderly; however, it is now […]
Repeated Low-Level Red-Light Therapy for Controlling Onset and Progression of Myopia-a Review
Repeated low-level red-light (RLRL), characterized by increased energy supply and cellular metabolism, thus enhancing metabolic repair processes, has gained persistent worldwide attention in recent years as a new novel scientific approach for therapeutic application in myopia. This therapeutic revolution led by RLRL therapy is due to significant advances in bioenergetics and photobiology, for instance, enormous […]
Shedding light on the importance of autophagy in AMD
Autophagy is a protective process that prevents oxidative damage in the eye. Recognition of this provides researchers with a new pathway to deal with age-related macular degeneration (AMD) and other retinal pathologies, according to Roberto Pinelli, MD, CEO and founder of the Switzerland Eye Research Institute, Lugano, Switzerland. He described the latest ideas about the […]
PHOTOBIOMODULATION THERAPY FOR LARGE SOFT DRUSEN AND DRUSENOID PIGMENT EPITHELIAL DETACHMENT IN AGE-RELATED MACULAR DEGENERATION: A Single-Center Prospective Pilot Study
Abstract Purpose: To evaluate visual acuity and morphologic changes after photobiomodulation (PBM) for patients affected with large soft drusen and/or drusenoid pigment epithelial detachment associated with dry age-related macular degeneration. Method: Twenty eyes with large soft drusen and/or drusenoid pigment epithelial detachment age-related macular degeneration were included and treated using the LumiThera Valeda Light Delivery System. All […]
The Effects of Modulated Light on the Visual Process
INTRODUCTION Light as medicine may seem like a new concept, but scientists have known since at least the late 1800s that certain wavelengths of light in prescribed doses can be used to heal the tissue [1,2]. For the eye and vision care community, light is being used as Intense Pulsed Light Therapy (IPL) for dry […]
Effects of Home Photobiomodulation Treatments on Cognitive and Behavioral Function, Cerebral Perfusion, and Resting-State Functional Connectivity in Patients with Dementia: A Pilot Trial
Abstract Objective: To examine the effects of transcranial and intranasal photobiomodulation (PBM) therapy, administered at home, in patients with dementia. Background: This study sought to replicate and build upon a previously published case series report describing improved cognitive function in five patients with mild-to-moderate dementia after 12 weeks of transcranial and intranasal near-infrared (NIR) PBM therapy. Materials […]