Abstract Purpose : The retina declines both structurally and functionally with age, with mitochondria playing a key role. Red to near-infrared (R-NIR) light in the region of λ670nm improves mitochondrial function and has been associated with improvements in color contrast sensitivity in preliminary studies of human retinal aging. This study tests the hypothesis that R-NIR light improves […]
Abstract: What can we expect from photobiomodulation therapy in patients with AMD?
Purpose : There are currently few treatment options available for the progression of RPE atrophy in non-exudative age-related macular degeneration (AMD). It is believed that individual oxidative stress, like in smoking, is a major clinical disease factor. In-vitro data demonstrate the protective anti-oxidative effect of photobiomodulation (PBM) when different wavelengths (in the visible and near-infrared range) of […]
Effect of Repeated Low-level Red Light on Myopia Prevention Among Children in China With Premyopia
Abstract Importance Myopia is a global concern, but effective prevention measures remain limited. Premyopia is a refractive state in which children are at higher risk of myopia, meriting preventive interventions. Objective To assess the efficacy and safety of a repeated low-level red-light (RLRL) intervention in preventing incident myopia among children with premyopia. Design, Setting, and Participants This was […]
Dry AMD therapy evolves with photobiomodulation
Take-home message: Non-invasive photobiomodulation may help dry age-related macular degeneration by causing regression of drusen and improving retinal function with benefits in visual acuity and contrast sensitivity. By Lynda Charters; Reviewed by Graham Merry, MBBS, and Marion R. Munk, MD, PhD Photobiomodulation (PBM) may be a new non-invasive, light- based treatment for patients with dry […]
Changes in the Brain Activity and Visual Performance of Patients with Strabismus and Amblyopia after a Compete Cycle of Light Therapy
Abstract This research assesses the brain activity and visual performance at baseline and after light therapy (LTH), of seventeen patients with strabismus and amblyopia (SA), and eleven healthy controls (HCs) from Querétaro, México. Quantitative electroencephalogram analysis (qEEG) was used to record the brain activity, and clinical metrics such as the visual acuity, angle of deviation, […]
Considerations for the Use of Photobiomodulation in the Treatment of Retinal Diseases
Abstract Photobiomodulation (PBM) refers to the beneficial effect produced from low-energy light irradiation on target cells or tissues. Increasing evidence in the literature suggests that PBM plays a positive role in the treatment of retinal diseases. However, there is great variation in the light sources and illumination parameters used in different studies, resulting in significantly […]
Photobiomodulation of the Visual System and Human Health
Abstract Humans express an expansive and detailed response to wavelength differences within the electromagnetic (EM) spectrum. This is most clearly manifest, and most studied, with respect to a relatively small range of electromagnetic radiation that includes the visible wavelengths with abutting ultraviolet and infrared, and mostly with respect to the visual system. Many aspects of […]
Photobiomodulation reduces drusen volume and improves visual acuity and contrast sensitivity in dry age-related macular degeneration
Abstract Purpose To evaluate the efficacy of photobiomodulation (PBM) treatment for patients with dry age-related macular degeneration (AMD). Methods Assessments on 42 eyes with dry AMD (age related eye disease study (AREDS) 2–4) were conducted. Multiwavelength light emitting diode (LED) light comprising of yellow (590 nm), red (670 nm) and near-infrared (790 nm) bandwidths was applied to subjects’ […]
Effect of Photobiomodulation in Suppression of Oxidative Stress on Retinal Pigment Epithelium
Abstract As the world undergoes aging, the number of age-related diseases has increased. One of them is disease related to retinal pigment epithelium (RPE) degeneration, such as age-related macular degeneration, causing vision loss without physical damage in the ocular system. It is the leading cause of blindness, with no cure. Although the exact pathogenesis is […]
Photobiomodulation Mediates Neuroprotection against Blue Light Induced Retinal Photoreceptor Degeneration
Abstract Potent neuroprotective effects of photobiomodulation with 670 nm red light (RL) have been demonstrated in several models of retinal disease. RL improves mitochondrial metabolism, reduces retinal inflammation and oxidative cell stress, showing its ability to enhance visual function. However, the current knowledge is limited to the main hypothesis that the respiratory chain complex IV, […]