Abstract SIGNIFICANCE These findings suggest that repeated low-level red-light therapy holds potential as a new method for managing myopia in children. PURPOSE This study aimed to compare and analyze the efficacy of repeated low-level red-light therapy and orthokeratology lenses for myopia control in children. METHODS Exactly 138 participants were enrolled in this retrospective study. Comprehensive […]
Safety of repeated low-level red-light therapy for myopia: A systematic review
Abstract Purpose Establishing the safety profile of repeated low-level red-light (RLRL) therapy is necessary prior to its widespread clinical implementation. Methods We conducted a systematic review (International Prospective Register of Systematic Reviews, CRD42024516676) of articles across seven databases from inception through February 10, 2024, with keywords related to myopia and RLRL therapy. Pooled safety outcomes […]
Investigating Red Light Therapy for Myopia Control
Since the growing popularity of repeated low-level red light (RLRL) in the past decade for myopia control, many researchers have been trying to understand the mechanism behind this treatment. RLRL therapy results do not match with classical emmetropization theory in that red light, which is a long wavelength, would focus behind the retina and therefore induce […]
Myopia Control Effect of Repeated Low-Level Red-Light Therapy Combined with Orthokeratology: A Multicenter Randomized Controlled Trial
Abstract Purpose To investigate the efficacy and safety of repeated low-level red-light(RLRL) therapy combined with orthokeratology(Ortho-k) among the children who, despite undergoing Ortho-k treatment, exhibited an axial elongation of at least 0.50mm over 1 year. Design Multicenter, randomized, parallel-group, single-blind clinical trial (ClinicaTrials.gov,NCT04722874). Participants Eligible children were aged 8-13 years with a cycloplegic spherical equivalent […]
Daily Low-Level Red Light for Spherical Equivalent Error and Axial Length in Children With Myopia
This randomized clinical trial evaluates the efficacy and safety of daily 650-nm low-level red light for myopia treatment among children aged 6 to 12 years in China. Key Points Question What is the effect of daily 650-nm low-level red light (LLRL) on spherical equivalent error (SER) and on axial length (AL)? Findings In this randomized […]
Myopia Control Effect of Repeated Low-Level Red-Light Therapy in Chinese Children: A Randomized, Double-Blind, Controlled Clinical Trial
Abstract Purpose: Repeated low-level red-light (RLRL) therapy is an emerging treatment for myopia control. Nevertheless, previous studies are limited by open-label design. Our study aimed to assess the efficacy and safety of RLRL therapy in controlling myopia progression compared to a sham device with only 10% of the original power. Design: Randomized, double-blind, controlled clinical trial. Participants: A […]
Longitudinal Changes and Predictive Value of Choroidal Thickness for Myopia Control after Repeated Low-Level Red-Light Therapy
Abstract Purpose: To evaluate longitudinal changes in macular choroidal thickness (mCT) in myopic children treated for 1 year with repeated low-level red-light (RLRL) therapy and their predictive value for treatment efficacy on myopia control. Design: A secondary analysis of data from a multicenter, randomized controlled trial (RCT; NCT04073238). Participants: Myopic children aged 8-13 years who participated in the RCT […]
Efficacy Comparison of Repeated Low-Level Red Light and Low-Dose Atropine for Myopia Control: A Randomized Controlled Trial
Abstract Purpose: To compare the treatment efficacy between repeated low-level red light (RLRL) therapy and 0.01% atropine eye drops for myopia control. Methods: A single-masked, single-center, randomized controlled trial was conducted on children 7 to 15 years old with cycloplegic spherical equivalent refraction (SER) ≤ -1.00 diopter (D) and astigmatism ≤ 2.50 D. Participants were randomly assigned […]
Effect of Repeated Low-Level Red-Light Therapy for Myopia Control in Children: A Multicenter Randomized Controlled Trial
Abstract Purpose: To assess the efficacy and safety of repeated low-level red-light (RLRL) therapy in myopia control in children. Design: Multicenter, randomized, parallel-group, single-blind clinical trial. Participants: Two hundred sixty-four eligible children 8 to 13 years of age with myopia of cycloplegic spherical equivalent refraction (SER) of -1.00 to -5.00 diopters (D), astigmatism of 2.50 D or less, […]
Axial Shortening in Myopic Children after Repeated Low-Level Red-Light Therapy: Post Hoc Analysis of a Randomized Trial
Abstract Introduction: Axial length (AL) elongation in myopia is considered irreversible. We aimed to systemically report unexpected AL shortening observed in a randomized clinical trial (RCT) after repeated low-level red-light (RLRL) therapy. Methods: This is a post hoc analysis of a multicenter, single-masked RCT. Two hundred sixty-four myopic children aged 8-13 years allocated to RLRL treatment (intervention […]